Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma

Adoptive transfer of chimeric antigen receptor-transduced T cells is a promising strategy for cancer immunotherapy.The CD38 molecule, with its high expression on multiple myeloma cells, appears a suitable target for antibody therapy.Prompted by this, we used three different CD38 antibody sequences to generate second-generation retroviral CD38-chime

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Evaluation of Interlaminar Stresses in Composite Laminates with a Bolt-Filled Hole Using a Linear Elastic Traction-Separation Description

Determination of the local DEODORANT SEXY SADIE interlaminar stress distribution in a laminate with a bolt-filled hole is helpful for optimal bolted joint design, due to the three-dimensional (3D) nature of the stress field near the bolt hole.A new interlaminar stress distribution phenomenon induced by the bolt-head and clamp-up load, which occurs

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